Rab GTPase-activating protein domain
نویسندگان
چکیده
Cristinel P. MÎINEA*1, Hiroyuki SANO*1, Susan KANE*, Eiko SANO*, Mitsunori FUKUDA†, Johan PERÄNEN‡, William S. LANE§ and Gustav E. LIENHARD*2 *Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, U.S.A., †Fukuda Initiative Research Unit, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan, ‡Institute of Biotechnology, Program in Cellular Biotechnology, FIN-00014, University of Helsinki, Helsinki, Finland, and §Harvard Microchemistry and Proteomics Analysis Facility, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, U.S.A.
منابع مشابه
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Constitutive transport of cellular materials is essential for cell survival. Although multiple small GTPase Rab proteins are required for the process, few regulators of Rabs are known. Here we report that EAT-17, a novel GTPase-activating protein (GAP), regulates RAB-6.2 function in grinder formation in Caenorhabditis elegans. We identified EAT-17 as a novel RabGAP that interacts with RAB-6.2, ...
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تاریخ انتشار 2005